PEGYLATION TECHNOLOGY: ADDRESSING CONCERNS, MOVING FORWARD

PEGylation technology: addressing concerns, moving forward

PEGylation technology, that is grafting of poly(ethylene glycol)(PEG) to biologics, vaccines and nanopharmaceuticals, has become a cornerstone of modern medicines with over thirty products used in the clinic.PEGylation of therapeutic proteins, nucleic here acids and nanopharmaceuticals improves their stability, pharmacokinetic and biodistribution.W

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Efficient separation of strontium ions from aqueous solution by dibenzo-18-crown-6 functionalized resin: Static and dynamic adsorption studies with computational DFT insights

The separation and utilization of radiotoxic 90Sr from liquid nuclear waste streams generated in the nuclear fuel reprocessing is highly desirable and challenging.Herein, we studied dibenzo-18-cown-6 functionalized chloromethyl-polystyrene (CMPS-DB18C6) resin which displays an excellent affinity toward Sr2+ion adsorption from aqueous solution.Adsor

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442 Female rats show a greater behavioral response to heroin across self-administration and locomotor sensitization compared to males

Objectives/Goals: Men and women with opioid use disorder (OUD) show differences in their initiation, use patterns, and outcomes that may have biological underpinnings.Here we present data directly comparing adult male and female rats across heroin-induced behaviors in order to provide insight into footjoy weste herren the nuances of sex differences

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